KMID : 0602619960020010077
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Korean Journal of Hepatology 1996 Volume.2 No. 1 p.77 ~ p.82
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A Case of Hypothyroidism Induced by Alpha-Interferon Therapy for Chronic Hepatitis B
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¿¬Á¾Àº/¹é¼¼Çö/±èÁøÈ£/¹Ú¿µÅÂ/º¯°ü¼ö/ÀÌâȫ
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Abstract
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Thyroid dysfunction has been reported as a side effect of alpha-interferon (IFN) therapy. The incidence of thyroid disorders was 1.2-12% during IFN therapy for chronic active hepatitis. We experienced a case of hypothyroidism developed after IFN
therapy
in a 48 year-old man with chronic hepatitis B.
Baseline thyroid function before IFN therapy was normal and thyroid autoantibodies were also negative. High tiers of antimicrosomal antibody and anti-thyroglobulin antibody appeared and severe hypothyroidism followed at 6 months after starting
the
IFN
therapy.
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KEYWORD
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